Cardiac Involvement in Sporadic Inclusion-Body Myositis

Images in Cardiovascular Medicine Cardiac Involvement in Sporadic Inclusion-Body Myositis

A 36-year-old man came to the emergency department with acute onset of exertional chest pain. He had had no recent infections, and no cardiovascular risk factors were present. However, the patient had used a wheelchair since his mid-20s because of sporadic inclusion-body myositis, as established by muscle biopsy. There were no other physical findings. Inflammatory markers and troponin T were no...

Ongoing Developments in Sporadic Inclusion Body Myositis

Sporadic inclusion body myositis (IBM) is an acquired muscle disorder associated with ageing, for which there is no effective treatment. Ongoing developments include: genetic studies that may provide insights regarding the pathogenesis of IBM, improved histopathological markers, the description of a new IBM autoantibody, scrutiny of the diagnostic utility of clinical features and biomarkers, th...

Myouclear Breakdown in Sporadic Inclusion Body Myositis

Sporadic inclusion body myositis: a continuing puzzle.

There is now compelling evidence that sporadic inclusion body myositis (sIBM) is a muscle-specific autoimmune disease in which both T and B-cells play a part and in which both cytotoxic muscle fibre necrosis and degeneration occur. However the factors responsible for breakdown of immune tolerance and the nature of the target antigens expressed by muscle fibres remain unknown. Genetic factors ar...

Sporadic inclusion body myositis: an unsolved mystery.

Sporadic inclusion body myositis (sIBM) is considered to be the most common acquired muscle disease associated with aging. It is a disabling disorder still without effective treatment. sIBM causes weakness and atrophy of the distal and proximal muscles. Involvement of quadriceps and deep finger flexors are clues to early diagnosis. Dysphagia in the course of the disease is common. Muscle biopsy...